The value of laboratory testing of ceruloplasmin, copper and urinary copper in detection of Wilson disesase.


Intermedica Laboratory, Faculty of Natural Sciences

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Wilson disease is a genetically determined copper accumulation disease that usually presents between 6 and 40 years, but it can affect older and younger as well. Disease results from lack or dysfunction of copper transporting ATP-ase. Copper is absorbed and transported to the liver, but the absence of a hepatocellular P-type ATP-ase prevents the incorporation of copper in ceruloplasmin, so copper accumulates in brain, kidney, liver and cornea. Urinary copper is increased as well.Cp is an α2-globulin that contains approximately 95 % of the total serum copper.

Hereby, measurement ofCp, copper and urinary copper are useful test for diagnose and this is the aim of our study.

For a period of ten years, are analyzed 341 patients suspect for Wilson disease from Albania and Kosovo, recommended from gastro-hepatology departaments. Methods used for measurements are immunoturbidimetric for Cp, colorimetry for copper and atomic absorption for urinary copper.

All data are analyzed with SPSS version 20 and Excel 2010.

As results ROC curve with combination of copper and ceruloplasmin increase sensitivity and specificity in detection of Wilson disease and two biomarkers correlate with each- other. The analysis of linear regression showed that decrease of ceruolplasmin increase the possibility to have Wilson disease.

Keywords: Ceruloplasmin, copper, urinary copper, regression, analysis etc.

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