Spontaneous tumors in dog as a model for comparative oncology


1Department of Preclinical Subjects, Faculty of Veterinary Medicine, Agricultural University of Tirana, ALBANIA

2 Private Veterinarian, Tirana, ALBANIA

*Corresponding author  e-mail: l.dhaskali@ubt.edu.al        

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Pet animals are a very important resource and a valuable tool to tumor studies because of they live their
biological life, and they live in the same ambient as human do. On the other hand, dog malignant mammary
tumors are very common in middle-aged animals and they are similar model with breast human cancer. These
tumors are appropriate and valid models to study cell cancer biology as well as to test new therapeutic drugs
against cancer so long as dog develop spontaneous tumors with biological and histopathologial features similar
to it occur in human. Dog may be an attractive model to study hormone dependence of cancer. Tumors with
probable relation to human cancer biology include mammary carcinoma, skin melanoma, oral squamous cell
carcinoma, soft tissues carcinoma, etc. Skin tumors, especially skin melanomas are malignant tumor more
common of dog. Metastasis is frequent and their relative resistance to chemo and radiotherapy make it an
interesting model to study. Squamous cell carcinoma is an excellent model for radiotherapy studding. Skin
tumors and soft tissues sarcoma are very good models for combined studding as chirurgical way with
chemotherapy or with biological response modifiers. The aim of this study was to put in evidence that skin and
mammary malignant tumors of dog may be used as an excellent model for comparative oncology.

Keywords: breast cancer, human, tumors, dog, oncology

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